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Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation-2:1 is downregulated in congenital heart disease and regulates cell proliferation by targeting HAND2

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

《医学前沿（英文）》 2021年第15卷第1期页码 91-100 doi: 10.1007/s11684-020-0778-5

摘要： Congenital heart disease (CHD) is the most common birth defect worldwide. Long non-coding RNAs (lncRNAs) have been implicated in many diseases. However, their involvement in CHD is not well understood. This study aimed to investigate the role of dysregulated lncRNAs in CHD. We used Gene Expression Omnibus data mining, bioinformatics analysis, and analysis of clinical tissue samples and observed that the novel lncRNA SAP30-2:1 with unknown function was significantly downregulated in damaged cardiac tissues from patients with CHD. Knockdown of lncRNA SAP30-2:1 inhibited the proliferation of human embryonic kidney and AC16 cells and decreased the expression of heart and neural crest derivatives expressed 2 (HAND2). Moreover, lncRNA SAP30-2:1 was associated with HAND2 by RNA immunoprecipitation. Overall, these results suggest that lncRNA SAP30-2:1 may be involved in heart development through affecting cell proliferation via targeting HAND2 and may thus represent a novel therapeutic target for CHD.

关键词： congenital heart disease Gene Expression Omnibus lncRNA SAP30-2:1 cell proliferation RNA immunoprecipitation HAND2

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RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1

《医学前沿（英文）》页码 924-938 doi: 10.1007/s11684-023-1004-z

摘要： Long noncoding RNAs (lncRNAs) play a crucial regulatory role in the development and progression of multiple cancers. However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear. In the current study, the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors. Gain- and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation, invasiveness, and metastasis of ovarian cancer cells in vivo and in vitro. Moreover, the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor prognosis. Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1, which is necessary for suppressing tumor metastasis and inhibiting KRAS signaling. Collectively, our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer, which may be a potential prognostic biomarker.

关键词： ovarian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1

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Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

《医学前沿（英文）》 2009年第3卷第4期页码 459-462 doi: 10.1007/s11684-009-0084-8

摘要： The aim of this paper was to investigate the prevalence of human papilloma virus (HPV) infection in women under 30 years old with cervical intraepithelial neoplasia (CIN) or cervical cancer, in order to provide a basis for cervical cancer prevention and treatment. We recruited 2052 female cases from the education system in Futian District, Shenzhen city, from April 2006 to April 2008, with age ranging from 22 to 60 years old. Second-generation hybrid capture test was done for detection of female genital tract HPV and cervical colposcopy for screening CIN or cervical cancer. The prevalence of HPV and cervical precancerous lesions or cervical cancer was evaluated in different age groups of women. The HPV positive rate was 247/2052 (12.00%), and 35/2052 (1.71%) of the cases were≥CIN I by pathological diagnosis. In the 22―29-year-old age group, there were 291 cases, including 39HPV-positive cases (13.40%) and one case of pathological diagnosis≥CIN I (0.34%), and there were 1761 cases in the 30―60-year-old age group, including 208 HPV-positive cases (11.81%) and 34 cases of pathological diagnosis≥CIN I (1.93%). The HPV-positive rate of 22―29-year-old age group was higher than that of 30―60-year-old age group, but the difference was not significant ( = 0.5967, = 0.4398); the CIN and cervical cancer detection rate of the former group was lower than that of the latter one, and the difference was not significant either ( = 3.7519, = 0.0527). The cases in 30―60-year-old age group were divided into five age sub-groups, and the HPV-positive rate of the 22―29-year-old age group was compared with the remaining groups, and it was found that the HPV-positive rate of the former group (13.40%) was lower than that of the 40―44-year-old age group (14.70%) but higher than that of the other four groups. Moreover, the difference in the HPV-positive rate between the 22―29-year-old age group and the 50―60-year-old age group (6.06%) was significant ( = 5.545, = 0.018), but the difference between the 22― 29-year-old age group and each of the other four groups was not significant (>0.05). In addition, the CIN and cervical cancer detection rate of the 22―29-year-old age group (0.34%) was lower than that of the remaining five groups, and the difference between the 22―29-year-old age group and the 35―39-year-old age group (2.26%), and between 22―29-year-old age group and 40―44-year-old age group (2.30%) was significant ( = 4.446, = 0.0035; = 4.525, = 0.0363, respectively), but the difference between the 22―29-year-old age group and each of other three groups was not significant (>0.05). Furthermore, 80.00% (28/35) cases of pathological diagnosis≥CIN I and 90.91% (10/11) lesions of pathological diagnosis≥CIN II occurred at 35―49 years of age. For many young women below the age of 30 who were infected with high-risk HPV were one-off infections, so it was not appropriate to recommend HPV detection as cervical precancerous lesions or cancer screening program for women less than 30 years old. The prevention and treatment of cervical cancer should be focused on those women more than 35 years of age.

关键词： cervical cancer human papilloma virus cervical intraepithelial neoplasia

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Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive

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《医学前沿（英文）》 2013年第7卷第3期页码 395-395 doi: 10.1007/s11684-013-0289-8

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基于半导体纳米晶体的神经突触器件 Review

步明轩1,2,王越1,2,尹蕾1,2,童周禹1,2,张懿强3,杨德仁1,2,4,5,皮孝东1,2,4,5

《信息与电子工程前沿（英文）》 2022年第23卷第11期页码 1579-1601 doi: 10.1631/FITEE.2100551

摘要：

近年来，人们对信息处理的需求日益增长，脑启发式神经形态器件得到了广泛的关注。突触器件作为一类重要的神经形态器件，在短短几年内迅速升温。在用于制备突触器件的各种材料中，半导体纳米晶体（NCs）因其优异的电学和光学性能而成为首选材料之一。本综述论文首先介绍了基于半导体纳米晶体的突触器件的研究背景及半导体纳米晶体的基本性质。然后，根据器件有源层所用纳米晶体种类的不同，分类介绍了基于纳米晶体的突触器件的最新研究进展。最后，讨论了基于半导体纳米晶体的突触器件目前仍面临的问题和挑战。

关键词：半导体纳米晶体；突触器件；神经形态计算

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Development of an integrated modeling system for improved multi-objective reservoir operation

Lei WANG, Cho Thanda NYUNT, Toshio KOIKE, Oliver SAAVEDRA, Lan Chau NGUYEN, Tran van SAP,

《结构与土木工程前沿（英文）》 2010年第4卷第1期页码 47-55 doi: 10.1007/s11709-010-0001-x

摘要： Reservoir is an efficient way for flood control and improving all sectors related to water resources in the integrated water resources management. Moreover, multi-objective reservoir plays a significant role in the development of a country’s economy especially in developing countries. All multi-objective reservoirs have conflicts and disputes in flood control and water use, which makes the operator a great challenge in the decision of reservoir operation. For improved multi-objective reservoir operation, an integrated modeling system has been developed by incorporating a global optimization system (SCE-UA) into a distributed biosphere hydrological model (WEB-DHM) coupled with the reservoir routing module. The new integrated modeling system has been tested in the Da River subbasin of the Red River and showed the capability of reproducing observed reservoir inflows and optimizing the multi-objective reservoir operation. First, the WEB-DHM was calibrated for the inflows to the Hoa Binh Reservoir in the Da River. Second, the WEB-DHM coupled with the reservoir routing module was tested by simulating the reservoir water level, when using the observed dam outflows as the reservoir release. Third, the new integrated modeling system was evaluated by optimizing the operation rule of the Hoa Binh Reservoir from 1 June to 28 July 2006, which covered the annual largest flood peak. By using the optimal rule for the reservoir operation, the annual largest flood peak at downstream control point (Ben Ngoc station) was successfully reduced (by about 2.4m for water level and 2500m·s for discharge); while after the simulation periods, the reservoir water level was increased by about 20m that could supply future water use.

关键词： distributed biosphere hydrological model (WEB-DHM) optimization multi-objective reservoir the Red River basin

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Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

《化学科学与工程前沿（英文）》 2014年第8卷第3期页码 276-279 doi: 10.1007/s11705-014-1426-x

摘要： The drug delivery scientists need to reexamine the advances made during the past 60 years, analyze our current abilities, and design the future technologies that will propel us to achieve the next level of drug delivery technologies. History shows that the first generation (1G) of drug delivery research during 1950–1980 was quite productive, while the second generation (2G) technologies developed during 1980–2010 were not as prolific. The ultimate goal of drug delivery research is to develop clinically useful formulations to treat various diseases. Effective drug delivery systems can be developed by overcoming formulation barriers and/or biological barriers. The engineering approach has a limit in solving the problem, if biological difficulties are not clearly identified and understood. The third generation (3G) drug delivery systems will have to focus on understanding the biological barriers so that they can be overcome by engineering manipulation of the drug delivery systems. Advances in the next 30 years will be most accelerated by starting open dialogues without any preconceived ideas on drug delivery technologies. The new generation of drug delivery scientists needs to be aware of the successes and limitations of the existing technologies to design the new technologies for meaningful advances in the future.

关键词： drug delivery history formulation barriers nanotechnology clinical product

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面向语义通信的模分多址技术 Research Article

张平1,2,3,许晓东1,2,3,董辰1,牛凯1,2,梁灏泰1,梁子键1,秦晓琦1,孙梦颖1,陈昊2,马楠1,2,许文俊1,王光宇1,陶小峰2,4

《信息与电子工程前沿（英文）》 2023年第24卷第6期页码 801-812 doi: 10.1631/FITEE.2300196

摘要：在多用户系统中，系统资源应分配给不同用户。在传统通信系统中，系统资源通常包括时间、频率、空间和功率，因此广泛使用诸如时分多址（TDMA）、频分多址（FDMA）、空分多址（SDMA）、码分多址（CDMA）、非正交多址（NOMA）之类多址技术。在被认为是下一代通信系统新范式的语义通信中，我们从语义角度，以基于模型的人工智能方法，从信源中提取高维语义域特征，并针对信源和信道特征联合构建模型信息空间。从模型信息空间中挖掘语义信息的共性化和个性化信息，提出一种新的基于语义域资源的多址技术，称为模分多址（MDMA）。从信息论角度，证明模分多址比传统多址技术获得更多性能提升。仿真结果表明，模分多址比传统多址技术节省更多带宽资源，并且在低信噪比条件下，在加性高斯白噪声（AWGN）信道中，相比非正交多址具有至少5 dB的性能优势。

关键词：模分多址（MDMA）；语义通信；多址技术

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我国地震预测成绩的回顾与统计

高建国

《中国工程科学》 2009年第11卷第6期页码 129-131

摘要：

地震预测预报的难度大，但并非了无痕迹或不可知，我国每次较大的地震都有案例总结。统计表明，近４０年来，有７７次地震在发生前均有中期、短期甚至临震预测，不能因为汶川地震预测的失败，就全面抹杀中国的地震预报成绩，即我国的地震预测成绩是应予肯定的，汶川地震也并非是无前兆的“怪震”。

关键词：地震地震预测中国近30 多年的地震预报统计

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基于玻璃通孔的Ka波段宽带滤波封装天线 Research Article

方针1,2,张继华1,2,3,高莉彬1,2,陈宏伟1,2,李文磊1,2,梁天鹏1,2,蔡旭东1,2,蔡星周3,贾惟聪3,郭欢3,李勇3

《信息与电子工程前沿（英文）》 2023年第24卷第6期页码 916-926 doi: 10.1631/FITEE.2200573

摘要： BPF单元有3对λg/4槽(缺陷微带结构)和两对λg/2 U形缝隙(缺陷地结构)。该天线实现了大带宽和高辐射效率，这可能与玻璃基板的叠加和玻璃通孔馈电有关。

关键词：滤波封装天线；玻璃通孔；三维封装器件；激光键合

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Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin

Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO

《化学科学与工程前沿（英文）》 2009年第3卷第2期页码 186-191 doi: 10.1007/s11705-009-0004-0

摘要： 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones and were synthesized in 41%-67% yield by using microwave-assisted one-pot protocol. The structures of the new compounds , , , , , , and - were confirmed by IR, NMR, MS, and elemental analysis. The antimicrobial activities of the compounds against pv. lachrymans (Smith et Bryan) Young, Dye & Wilkie, Pers., and Blum. were examined. Some of the compounds showed good antifungical activity against Blum.

关键词： microwave-assisted synthesis naphthyl thiazolidin-4-one antimicrobial

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磁控溅射法生长的带隙可调谐(GaxIn1−x)2O3 Research Articles

张法碧1,孙巾寓1,李海鸥1,周娟1,王荣1,孙堂友1,傅涛1,肖功利1,李琦1,刘兴鹏1,张秀云1,郭道友2,王相虎3,秦祖军1

《信息与电子工程前沿（英文）》 2021年第22卷第10期页码 1370-1378 doi: 10.1631/FITEE.2000330

摘要：采用磁控溅射技术和热退火技术在(0001)蓝宝石衬底上制备了多组分氧化物(GaxIn1−x)2O3薄膜，实现可调带隙。详细研究了三元化合物(GaxIn1−x)2O3在整个组成范围内的光学性质和能带结构演化。X射线衍射谱表明，Ga含量在0.11至0.55之间的(GaxIn1−x)2O3薄膜既有立方结构，也有单斜结构，而Ga含量高于0.74的(GaxIn1−x)2O3薄膜只有单斜结构。实验结果为透明导电化合物半导体(GaxIn1−x)2O3薄膜在光电和光伏行业的应用，特别是在显示器、发光二极管和太阳能电池的应用奠定了基础。

关键词： (GaxIn1−x)2O3薄膜；带隙可调谐；磁控溅射

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一种基于业务需求与流量感知的卫星网络多路径路由算法 Research Article

邢紫阳1,2,祁晖1,2,底晓强1,2,3,刘晋尧1,2,许睿1,2,陈静1,2,从立钢1,2

《信息与电子工程前沿（英文）》 2023年第24卷第6期页码 844-858 doi: 10.1631/FITEE.2200507

摘要：随着低轨卫星制造和发射成本的降低，以及其覆盖范围大、数据传输速率高等优点，低轨卫星已成为空地网络数据传输的重要组成部分。但受地理位置及人们生活习惯等因素影响，用户对数据需求差异会造成网络流量不均衡，可能导致网络拥塞进而影响数据传输。传统卫星网络获取网络信息收敛慢，无法细粒度收集全局网络信息，不利于计算最优路由。多业务请求无法满足服务质量要求。本文将人工智能技术应用于低轨卫星网络，利用软件定义网络获取全局网络信息，感知网络流量，通过强化学习在线制定综合决策，实时更新最优路由策略。仿真结果表明，所提强化学习算法有良好收敛性和较强泛化能力。与传统路由相比，本文算法吞吐量提高了8%，且具有负载均衡性。

关键词：软件定义网络（SDN）；快速用户数据报协议互联网连接（QUIC）；强化学习；Sketch；多业务需求；卫星网络

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金属网栅透明导电膜光电性能综合评价因子 Research Articles

张怡蕾1,2,曹瑾璇1,2,陆振刚1,2,王赫岩1,2,谭久彬1,2

《信息与电子工程前沿（英文）》 2021年第22卷第11期页码 1532-1540 doi: 10.1631/FITEE.2000690

摘要：获取金属网栅最佳光电性能（零级光学透光率、电磁屏蔽效能和杂散光均匀性）对其在透明电磁屏蔽领域的应用具有重要价值。然而，目前相关研究较少。本文提出一种基于金属网栅光电性能的形式简单的综合评价因子Q，可简便有效地用于不同结构参数的金属网栅光电性能评估。评价因子Q值与TOPSIS的评估结果变化趋势一致，验证了评价因子Q的有效性。评价因子Q还可以对不同图案的金属网栅光电性能进行评估，使其在金属网栅的设计和应用中具有十分广泛的应用前景。

关键词：金属网栅；TOPSIS法；熵权法；综合评价因子；透明导电膜

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流体内磁驱动微米机器人运动前沿研究综述 Review Article

苗佳淼1,2,王潇朴2,周燕2,叶敏2,赵洪宇2,许若愚1,钱辉环1,2

《信息与电子工程前沿（英文）》 2023年第24卷第11期页码 1520-1540 doi: 10.1631/FITEE.2300054

摘要：磁驱动微米机器人能够在人体内局部低侵入性地执行特定任务。为到达体内病灶区域，微米机器人常常需要在比静止液体更为复杂的流动血液内进行导航运动。因此，相应的精准控制方案设计更具挑战性。目前已有许多关于磁控微米机器人在流体内的运动控制及其理论研究。本文回顾总结了有关磁控微米机器人在流体中的最新研究进展，包括流动系统的建立、运动的动力学建模以及控制方法。此外，讨论了当前面临的挑战和局限性。希望本文为微米机器人在复杂流体环境中的高效控制提供新的思路，并加快微米机器人在临床应用中的研究。

关键词：微米机器人；流体；动力学建模；控制

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标题作者时间类型操作

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

期刊论文

RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the miR-627-3p/SPRED1

期刊论文

Epidemiological studies of women under age 30 infected with human papillomavirus

Zhihua LIU MD, Qing LI BM, Weihong LI BM,

期刊论文

Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive

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